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Chronic Fatigue Syndrome (CFS)

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On 23/05/2025
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Chronic Fatigue Syndrome (CFS), also known as Myalgic Encephalomyelitis (ME), is a complex medical condition characterized by severe and persistent fatigue that is not alleviated by rest. This condition persists for more than six months and leads to significant functional impairment in both physical and cognitive domains.

Clinical Features of the Syndrome:

Core symptoms of CFS include:

  1. Unrelenting Fatigue: A profound and persistent feeling of physical and mental exhaustion that is not improved by rest or sleep.
  2. Sleep Dysregulation: Patients often experience insomnia or fragmented sleep, accompanied by a sensation of non-restorative sleep.
  3. Cognitive Impairment: Often referred to as “brain fog,” this involves slowed mental processing, difficulty concentrating, and short-term memory issues.
  4. Generalized Pain: Including chronic headaches, myalgia (muscle pain), and arthralgia (joint pain) without inflammatory markers.
  5. Post-Exertional Malaise (PEM): A hallmark symptom of CFS, characterized by exacerbation of symptoms following minimal physical or mental exertion.

Relationship Between Muscle Mass and CFS:

Although sarcopenia (loss of muscle mass) is not a direct cause of CFS, it may contribute to symptom severity:

  1. Muscular Weakness and Decreased Functional Capacity: Reduced muscle mass correlates with diminished ability to perform daily activities.
  2. Energy Metabolism Disruption: Skeletal muscle plays a vital role in glucose and lipid metabolism; reduced muscle mass impairs energy production efficiency.
  3. Prolonged Recovery Time: Muscle weakness leads to delayed recovery post-exertion.

Therapeutic Considerations:

Symptom management includes:

  • Graded exercise therapy and physical rehabilitation.
  • Cognitive behavioral therapy (CBT).
  • Nutritional support through amino acids and appropriate supplementation.
  • Energy conservation strategies and activity pacing.

Herbal Supplements That May Aid Recovery:

General References: